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Attractin Site - The Study of the Attractin Protein

The Attractin Site

Study of attractin provides insight into transcript variation, protein-protein interactions and how a single protein can influence different processes dependent upon tissue-specific expression 

Genes
​Use the Genes link above to examine and visualize the large number of spontaneous mutations pointing to attractin's function, and how the unique introduction of a LINE-1 element in primates provides a novel mechanism for alternatively-spliced variants.
Proteins
Attractin appears to be a member of a very small family that share extracellular domain motifs and organization, and share short cytoplasmic domain motifs not found in any other protein. Explore the relation between attractin, attractin-like protein, and multiple EGF-like domains 8 (MEGF8) protein using the Proteins link above.
 Function
At present, function is inferred from aberrations seen in mutants in vivo and by characterization of properties derived cells in vitro. Through the Function link above, discover how research suggests a role in vesicular transport, with consequences for extracellular proteoglycan release, consequential effects upon positively-charged peptide signaling, and possible involvement in delivering new membrane to the cell surface.
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