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Attractin Site - The Study of the Attractin Protein

The Attractin Site

​Gene-specific PubMed Links (MEGF8, MGRN1, PEPD)

​MEGF8

2018
The Drosophila homologue of MEGF8 is essential for early development Abstract Full
CRISPR Screens Uncover Genes including Megf8 and Mgrn1 (mahogunin) that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog
Abstract Full

2017
Rare mutations in MEGF8 related to schizophrenia
Abstract Full

2014
Targeted discovery and validation of plasma biomarkers of Parkinson's disease.
Abstract Full

2013
MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons.
Abstract

2012
Engulfing astrocytes protect neurons from contact-induced apoptosis following injury.
Abstract Full
Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.
Abstract Full

2009
Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy
Abstract Full

1998
Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening
Abstract

Mahogunin (Mgrn1)

2019
Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases.
Abstract Full
Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis.
Abstract
Calmodulin regulates MGRN1-GP78 interaction mediated ubiquitin proteasomal degradation system.
Abstract

2018
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Abstract Full
Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.
Abstract Full

2017
E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion.
Abstract Full
MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport.
Abstract Full
Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins.
Abstract Full
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.
Abstract Full
Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus.
Abstract Full
MC1R signaling. Intracellular partners and pathophysiological implications.
Abstract Full

2016
Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.
Abstract
Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.
Abstract
Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model.
Abstract Full

2015
Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101.
Abstract Full
Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms.
Abstract
Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease.
Abstract

2014
Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity.
Abstract Full
Mahogunin-mediated tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
Abstract Full

2013
Functional conservation between mammalian MGRN1 and plant LOG2 ubiquitin ligases.
Abstract Full
RML prions act through Mahogunin and Attractin-independent pathways.
Abstract Full
Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity.
Abstract Full
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease.
Abstract Full
MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.
Abstract Full

2012
The effect of mahogunin gene mutant on reproduction in male mice: a new sight for infertility?
Abstract

2011
The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor.
Abstract
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.
Abstract Full

2009
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas.
Abstract Full
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.
Abstract Full
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.
Abstract Full
Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes; a cAMP independent pathway.
Abstract Full
Transgenic analysis of the physiological functions of Mahogunin Ring Finger-1 isoforms.
Abstract Full

2007
Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice.
Abstract Full
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.
Full

2006
Characterization of Mahogunin Ring Finger-1 expression in mice.
Abstract
Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis.
Abstract Full
The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity.
Abstract Full

2005
[Distribution of Mahoganoid protein its mRNA in the testes and epididymides of mature male rats].
Abstract

2003
Spongiform degeneration in mahoganoid mutant mice.
Abstract

2002
The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.
Abstract Full

1997
Genetic studies of the mouse mutations mahogany and mahoganoid.
Abstract Full

1986
Position of Igl-1, md, and Bst loci on chromosome 16 of the mouse.
Abstract

Dark-like (Dal)/Prolidase (PEPD)

2019
Prolidase enzyme is required for extracellular matrix integrity and impacts on postnatal cerebellar cortex development.
Abstract

2014
Lack of prolidase causes a bone phenotype both in human and in mouse
Abstract
Brain morphological effects in prolidase deficient mice: first report
Abstract Full

2011
Developmental cardiac hypertrophy in a mouse model of prolidase deficiency
Abstract

2008
Genetic and phenotypic studies of the dark-like mutant mouse
Abstract

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